The book begins by tracing the spread of the virus from its origins in Wuhan, China to its rapid spread around the world. Lewis discusses the various ways in which people and institutions responded to the pandemic, including measures such as lockdowns, social distancing, and mask-wearing.

Through interviews with scientists, government officials, and everyday people, Lewis examines the factors that contributed to the rapid spread of the virus. He looks at how the virus was initially misdiagnosed and underestimated, and how it was able to spread so quickly due to global interconnectedness and the failure of some governments to take decisive action.

The book also explores the ways in which the pandemic exposed and exacerbated preexisting inequalities and injustices, particularly in terms of how it disproportionately affected marginalized communities. Lewis discusses how the pandemic disproportionately affected people of color, the elderly, and low-income individuals, and how it highlighted the importance of universal access to healthcare.

Lewis looks at the impact of the pandemic on global systems and economies, including the disruption of supply chains, the collapse of industries such as travel and hospitality, and the shift to remote work. He also discusses the social and psychological effects of the pandemic, including the isolation and loneliness caused by lockdowns and the mental health impacts of the crisis.

The book ends by considering the long-term consequences of the pandemic and how it may shape the future. Lewis discusses the potential for future pandemics and the importance of preparedness, and he reflects on the ways in which the pandemic has changed the world and how it has brought to light the interconnectedness of all people and nations.